Ghulam Rasool Mashori
PUMHS for Women, Pakistan
Title: Effects of Captopril & Lisinopril (ACE Inhibitor drugs) on Insulin Release
Biography
Biography: Ghulam Rasool Mashori
Abstract
Treatment of hypertension (asymptomatic disease) is based on the hypothesis that, BP will prevent or decrease cardiovascular complications. Treatment of elevated BP has lessened the occurrence of stroke, heart and renal failure. However, the prevalence of Coronary Heart Disease (CHD) is not reduced to the same degree. Many of the drugs promoted as first line drugs, has been shown to affect on insulin release in both the diabetic and non diabetic hypertensive patients consequently may lead to the development of CHD. Since 1990’s mono therapy for the treatment of hypertension has been advocated, Captopril & Lisinopril may be used as a first line therapy. The purpose of the study was, to compare the effect of ACE inhibitors on insulin release by using rat isolated pancreas through perfusion technique. Diazoxide was used as positive control (insulin suppressant). Doses used were based on therapeutic peak plasma concentrations. Both Captopril (1µg/ml) & Lisinopril (150ng/ml) did not significantly suppressed insulin release. In conclusion Captopril and Lisinopril had no effect on Insulin release.